Simulation of thermal effects of high intensity focused ultrasound.
MRI monitoring of ultrasonic heating.
Ultrasonic tissue characterization.
MR-compatible robotics.
MRI coil design
Sonothrombolysis
Brain ablation
Skull phantoms
Motion phantoms
Hynynen K., Damianou C., Darkazanli A., Unger E., Schenck J., "The feasibility of using MRI to monitor and guide noninvasive ultrasound surgery", Ultrasound Med. Biol., Vol. 19 (1), pp. 91-92, 1992.
Hynynen K., Damianou C., Alexander A., Unger E., Cline H., Schenck J., "Demonstration of MR-guided Noninvasive US surgery of the Kidney", Radiology, Vol.189(Suppl), pp. 224, 1993.
Damianou C., Hynynen K., "Focal spacing and near-field heating during pulsed high temperature ultrasound therapy", Ultrasound Med. Biol., Vol. 19 (9), pp. 777-787,1993.
Damianou C., Hynynen K., "The effects of various physical parameters on the size and shape of necrosed tissue volume during ultrasound surgery", J. of Acoust. Soc. Am., Vol. 95 (3), pp. 1641-1649,1993.
Hynynen K., Darkazanli A., Damianou C., Unger E., Schenck J., "Tissue thermometry during ultrasound exposure", Eur. Urol., Vol. 23 (suppl 1), pp. 12-16, 1993.
Hynynen K., Darkazanli A., Damianou C., Unger E., Schenck J., "The usefulness of a contrast agent and Gradient-Recalled Acquisition in a Steady-State Imaging sequence for Magnetic Resonance Imaging-Guided noninvasive ultrasound surgery", Inv. Radiology, Vol. 29 (10), pp. 897-903, 1994.
Vykhodtseva N., Hynynen K., Damianou C., "Pulse duration and peak intensity during focussed ultrasound surgery: Theoretical and experimental effects in rabbit brain in vivo", Ultrasound in Med. & Biol., Vol. 20 (9), pp. 987-1000, 1994.
Vykhodtseva N., Hynynen K., Damianou C., "Histologic effects of high Intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in, vivo”, Ultrasound Med. Biol., Vol. 21(7), pp. 696-979, 1995.
Hynynen K., Damianou C., Collucci V., Unger E., Cline H., Jolesz F., "MR monitoring of focused utrasonic surgery of renal cortex: Experimental and simulation studies", JMRI, Vol. 5(3), 259-266, 1995.
Maass R., Damianou C., Sanghvi N., "Tissue temperature estimation during focussed ultrasound ablation using pulse-echo techniques", Ultrasonic Imaging 17, 60-61, 1995.
Damianou C., Hynynen K., Fan X., "Evaluation of accuracy of a theoretical model for predicting the necrosed tissue volume during focused ultrasound surgery", IEEE Trans. on Ultrasonics, Ferroelectrics, and frequency Control, Vol. 42 (2), pp. 182-187, 1995.
Roberto Maass-Moreno, Damianou C. "Noninvasive temperature estimation in tissue via ultrasound echo shifts. Part I: Analytical model", Journal of Acoustical Society of America, Vol. 100, pp. 2414-2521, 1996.
Roberto Maass-Moreno, Damianou C., and Narendra T. Sanghvi "Noninvasive temperature estimation in tissue via ultrasound echo shifts. Part II: in vitro study", Journal of Acoustical Society of America, Vol. 100, pp. 2522-2530, 1996.
Damianou C., Sanghvi N., Fry F., Maass R., "Dependence of Ultrasonic attenuation and absorption in dog soft tissues on temperature and thermal dose", Journal of Acoustical Society of America, Vol. 102(2), pp. 628-634, 1997.
C. Damianou, "In vitro and in vivo ablation of porcine renal tissues using High Intensity focused Ultrasound", Journal of Ultrasound in Medicine and Biology, Vol. 29 (9), pp. 1321-1330, 2003
Christakis Damianou, M. Pavlou, O. Velev, K. Kyriakou, M. Trimikliniotis ‘High intensity focused ultrasound ablation of kidney guided by ΜRI’, Journal of Ultrasound in Medicine and Biology Vol. 30 (3), pp. 397-404, 2004
C. Damianou “MRI monitoring of the effect of tissue interfaces in the penetration of high intensity focused ultrasound in kidney in vivo” Journal of Ultrasound in Medicine and Biology , Vol. 30 (9), pp. 1209-1215, 2004.
Damianou, C., Ioannides, K., Milonas, ‘Positioning device for MRI-guided high intensity focused ultrasound system’, Computer-Assisted Radiology and Surgery, 2 (6) pp. 335-345, 2008.
C. Damianou, Ioannides K., Hadjisavas V., Milonas N., Couppis A, Iosif D, ‘In vitro and in vivo brain ablation created by high intensity focused ultrasound and monitored by MRI’, IEEE Transaction on Ultrasonics, Ferroelectrics and Frequency Control, 56(6), pp. 1189-1198, 2009.
Couppis A., Damianou C., Kyriakou P., Lafon C., Chavrier F., Chapelon JYy, Birer A.’Heart ablation using a planar rectangular high intensity ultrasound transducer and MRI guidance’, Ultrasonics, 52, 821-829, 2012.
Mylonas, N. and Damianou, C. (2013), MR compatible positioning device for guiding a focused ultrasound system for the treatment of brain deseases. Int. J. Med. Robotics Comput. Assist. Surg.. doi: 10.1002/rcs.1501
Damianou C., Hadjisavvas V., Mylonas N., Couppis, A., Ioannides K., ‘MRI-Guided Sonothrombolysis of Rabbit Carotid Artery’, Journal of Stroke and Cerebrovascular Diseases, Vol 22 (7), pp. 1033-103, 2014.
Yiallouras C., Mylonas N., Damianou C. ‘MR compatible positioning device for guiding a Focused ultrasound system for transrectal treatment of prostate cancer’, Computer-Assisted Radiology and Surgery, DOI 10.1007/s11548-013-0964-x
2013.
Mylonas N., Damianou C. ‘A Prototype MR Compatible Positioning Device for Guiding a Focused Ultrasound System for the Treatment of Abdominal and Thyroid Cancer, International Journal of monitoring and surveillance technologies research, October-December, Vol.1 (4), pp. 48-61, 2013.
Damianou C., Hadjisavvas V., Ioannides K., ‘In vitro and in vivo evaluation of an MRI-guided focused ultrasound system for dissolving clots in combination with thrombolytic drugs’,Journal of Stroke and Cerebrovascular Diseases, Apr 2014 Apr 29. Epub 2014 Apr 29.
Damianou C., Hadjisavvas V., Mylonas N., Couppis, A., Ioannides K., ‘MRI-Guided Sonothrombolysis of Rabbit Carotid Artery’, Journal of Stroke and Cerebrovascular Diseases, Vol 23 (2), pp. e113-21, 2014.
Yiallouras C., Damianou C., ’Review of MRI positioning devices for guiding focused ultrasound systems’, Int J Med Robotics Comput Assist Surg, 11 (2); (2014), Published online in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/rcs.1601.
Menikou G, Dadakova T, Pavlina M, Bock M, Damianou C., MRI compatible head phantom for ultrasound surgery. Ultrasonics. 2015, Mar; 57:144-52. doi: 10.1016/j.ultras.2014.11.004. Epub 2014 Nov 20.
Damianou C., Christofi C., Mylonas N., ‘Removing atherosclerotic plaque created using high cholesterol diet in rabbit using ultrasound’, Journal of Therapeutic Ultrasound, (2015) 3:3, DOI 10.1186/s40349-015-0025-8.
Yiallouras C., Ioannides C., Dadakova T., Pavlina M., Bock M., Damianou C., ‘Three axis MR conditional robot for high intensity focused ultrasound for treating prostate diseases’, Journal of Therapeutic Ultrasound, 2015, 3:2, DOI 10.1186/s40349-014-0023-2.
Epaminonda E, Drakos T, Kalogirou C, Theodoulou M, Yiallouras C, Damianou C., MRI guided focused ultrasound robotic system for the treatment of gynaecological tumors, Int J Med Robot. 2016 Mar; 12 (1):46-52. doi: 10.1002/rcs.1653
Yiannakou M, Trimikliniotis M, Yiallouras C, Damianou C. Evaluation of focused ultrasound algorithms: Issues for reducing pre-focal heating and treatment time. Ultrasonics. 65 (2016), pp. 145-153. doi: 10.1016/j.ultras.2015.10.007.
Sagias G., Yiallouras C., Ioannides K., Damianou C., An MRI-conditional motion phantom for the evaluation of high-intensity focused ultrasound protocols, Int J Med Robot. 2016 Sep;12(3):431-41. doi: 10.1002/rcs.1709. Epub 2015 Sep 29.
C. Damianou, A. Couppis, ‘Feasibility study for removing calcified material using a planar rectangular ultrasound transducer, Journal of Ultrasound, 19 (2), pp 115-123, 2016.
N. Papadopoulos, C. Damianou, ‘In vitro evaluation of focused ultrasound enhanced TNK-TPA mediated thrombolysis’ Journal of Stroke and Cerebrovascular Diseases, ;25(8):1864-77, 2016.
G. Menikou, C. Yiallouras, M. Yiannakou, C. Damianou, ‘MRI guided Focused Ultrasound Robotic System for the Treatment of bone cancer’, Int J Med Robotics Comput Assist Surg 2017; 13: e1753.
Menikou G., Yiannakou M., Yiallouras C., Ioannides C., Damianou C., ‘MRI-compatible bone phantom for evaluating ultrasonic thermal exposures’, Ultrasonics. 2016 Sep;71:12-9. doi: 10.1016/j.ultras.2016.05.020.
N. Papadopoulos, C. Yiallouras, C. Damianou, The enhancing effect of focused ultrasound on TNK- Tissue Plasminogen Activator induced thrombolysis using an in vitro circulating flow model", J Stroke Cerebrovasc Dis. 2016 Dec; 25(12):2891-2899. doi: 10.1016/j.jstrokecerebrovasdis.2016.07.052.
E. Dall’Ara,M. Boudiffa ,C. Taylor, D. Schug, E. Fiegle, A.J. Kennerley, C. Damianou, G.M. Tozer, F. Kiessling, R. Müller , Longitudinal Imaging of the Ageing Mouse, Mech Ageing Dev. 2016 Dec;160:93-116. doi: 10.1016/j.mad.2016.08.001.
. C. Damianou, M. Yiannakou, G. Menikou, C. Yiallouras, ‘MRI guided coupling for a Focused Ultrasound system using a top to bottom propagation’, Journal of Therapeutic Ultrasound, accepted Oct 2016.
. N. Papadopoulos, G. Menikou, M. Yiannakou, C. Yiallouras, K. Ioannides, C. Damianou, ‘Evaluation of a small flat rectangular therapeutic ultrasonic transducer intended for intravascular use’, Ultrasonics 74 (2016), 196–203.
N. Papadopoulos, C. Damianou, ‘Microbubble-based sonothrombolysis using a planar rectangular ultrasonic transducer’, Journal of Stroke and Cerebrovascular Diseases, 2016.
M. Yiannakou, G. Menikou C. Yiallouras, K. Ioannides, C. Damianou, MRI guided focused ultrasound robotic system for animal experiments, accepted in the International Journal of Medical Robotics and Computer Assisted Surgery, Dec 2016.
G. Menikou, C. Damianou, ‘Acoustic and thermal characterization of agar based phantoms used for evaluating focused ultrasound exposures’, Journal of Therapeutic Ultrasound (2017) 5:14.
T. Alecou, M. Yiannakou, C. Damianou, ‘Amyloid beta plaque reduction with antibodies crossing the blood brain barrier opened in 3 sessions with focused ultrasound in a rabbit model’, Journal of ultrasound in medicine.
G. Menikou, M. Yiannakou, C. Yiallouras, C. Ioannides, C. Damianou, ‘MRI-compatible breast/rib phantom for evaluating ultrasonic thermal exposures’, The International Journal of Medical Robotics and Computer Assisted Surgery.
N. Papadopoulos, C. Damianou, ‘Microbubble-based sonothrombolysis using a planar rectangular ultrasonic transducer’, Journal of Stroke and Cerebrovascular Diseases.
C. Damianou participated in several grants related to:
An introduction to the field of bioengineering, including the application of engineering principles and methods to problems in biology and medicine and the integration of engineering with biology. Application of analytic methods from Statistics, Mathematics and Computer Science to biological data so as to extract useful knowledge. Introduction to Bioinformatics. Pairwise sequence alignment and multiple sequence alignment algorithms. Statistical significance of alignment results. Phylogenetic prediction. Database searching for similar sequences, efficiency of relevant algorithms. Protein classification and structure prediction. Statistical analysis of DNA microarray experimental data. Special topics include, biomechanics and biomaterials, bioprocessing and telemedicine, biomedical instrumentation, signal processing and imaging modalities. Introduction to the emerging medical devices industry.
The course examines the physical principles of ultrasound, magnetic resonance imaging (MRI) and optical coherence tomography (OCT), In ultrasonography emphasis will be given on issues such as interaction of ultrasound and soft tissue, Doppler ultrasound, artifacts, design of ultrasonic transducers and wave equations. In MRI emphasis will be given on issues such as creation of magnetization, resonance, MRI hardware, imaging in 2 dimensions, fast sequences and physical properties of different specialized MRI pulse sequences.
The course examines the physical principles of X-ray imaging, computed tomography (CT), single photon emission tomography (SPECT) and positron emission tomography (PET). In X-rays emphasis will be given on photo electric effect, Compton Effect, X-ray tube design, radon transformation, and reconstruction algorithms. PET includes Cyclotron operating principles and design, PET/CT and PET/MRI.
Review of image guided therapies such as Radiofrequency ablation, lasers, microwave and cryoablation. The course will examine the basic operating principles of therapeutic ultrasound, the concept of acoustic attenuation, measuring the intensity of therapeutic ultrasound, hardware of therapeutic ultrasound systems, measuring acoustic field, and the cavitation mechanism. The course will also include the basic imaging and guiding methods: ultrasound guidance, imaging with ultrasonic elastography and MRI guidance. Operating principles of MRI. Basic MRI sequences. The course will also include various applications such as therapeutic ultrasound and its synergy with drugs, treatment of Prostate cancer, treatment of gynecological tumors, treatment of brain diseases (Parkinson's, BBB), MRI-compatible robots, Lithotripsy, histotripsy and interaction of ultrasound and microbbubles.